Fig 2: IFN-ß and IFN-? protein expression are increased in DM skin.IHC of healthy control or 2 DM lesional biopsies (representative out of 8 patients) for the IFN-regulated protein MX1 and IFN-a, IFN-ß, and IFN-?. Original magnification, ×20.

Fig 3: DM skin lesions demonstrate a strong IFN signature.(A) Principal components analysis of differentially expressed genes (DEGs) between lesional DM biopsies and healthy control skin. (B) IPA identifying key pathways in the DM DEG list. (C) Graphical representation of log2 mRNA expression values of IFN genes from DM lesional skin microarrays. Bars depict SD. (D) IFN score comparison between DM and healthy control biopsies. The box plots depict the minimum and maximum values (whiskers), the upper and lower quartiles, and the median. The length of the box represents the interquartile range.